Police said both men were transported to UofL Hospital.
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LMPD's Homicide Unit is conducting a death investigation.
Police believe the man was crossing Cane Run Road east to west when he was hit by a car that was traveling southbound.
The shooting was reported in the 5200 block of Kaufman Lane around 6:50 p.m. Thursday, police said.
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According to court documents, Jalen Forrest was charged with murder Tuesday morning, just after 10 a.m.
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One person is in custody.
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Louisville Metro Police said at about 1:15 a.m., two men showed up at UofL Health Mary and Elizabeth Hospital with gunshot wounds.
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Frederick Matthews, age 37, is charged with murder and burglary.
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The man was rushed to University Hospital, where he was later pronounced dead.
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According to court documents, 29-year-old Dekoda Stinson was arrested just before 3 p.m. on Wednesday.